Hoehme Lab • Research group
Multicellular systems biology • Image analysis • Multiscale liver models

Hoehme S (2016)
Der Regeneration der Leber auf der Spur
Systembiologie.de Journal, Ausgabe 11 (Download), December 2016, p.66-69

S. Hoehme, A. Friebel, S. Hammad, D. Drasdo, and J.G. Hengstler (2016)
Creation of Three-dimensional Liver Tissue Models from Experimental Images for Systems Medicine
in Book Hepatocyte Transplantation (Methods and Protocols)
Editors: P. Stock B. Christ, Springer, ISBN 978-1-4939-6504-5

Ghallab, A., Henkel, S.G., Cellière, G., Driesch, D., Hoehme, S., Hofmann, U., Zellmer, S., Godoy, P., Sachinidis, A., Blaszkewicz, M., Reif, R., Marchan, R., Kuepfer, L., Häussinger, D., Drasdo, D., Gebhardt, R., Hengstler, J.G. (2015)
Model guided identification and therapeutic implications of an ammonia sink mechanism
Journal of Hepatology, April 2016 Volume 64, Issue 4, Pages 860–871

Friebel A., Neitsch J, Johann T, Hammad S, Henstler JG, Drasdo D, Hoehme S (2015)
TiQuant: Software for tissue analysis, quantification and surface reconstruction
Bioinformatics, 31 (19): 3234-3236

L.A.D'Alessandro, S. Hoehme, A. Henney, D. Drasdo and U. Klingmueller (2014)
Unraveling liver complexity from molecular to organ level: Challenges and perspectives
Progress in Biophysics and Molecular Biology, 117 (1), 78-86

Dirk Drasdo, Johannes Bode, Uta Dahmen, Olaf Dirsch, Steven Dooley, Rolf Gebhardt, Ahmed Ghallab, Patricio Godoy, Dieter Häussinger, Seddik Hammad, Stefan Hoehme, Hermann-Georg Holzhütter, Ursula Klingmüller, Lars Kuepfer, Jens Timmer, Marino Zerial, Jan G. Hengstler (2014)
The virtual liver: state of the art and future perspectives
Archives of Toxicology, December 2014, Volume 88, Issue 12, pp 2071-2075
Citations ISI (11.2015): 7

Dirk Drasdo, Stefan Hoehme, Jan G. Hengstler (2014)
How predictive quantitative modeling of tissue organization can inform liver disease pathogenesis
Journal of Hepatology, 61 (4), 951-956
Citations GS (11.2015): 10

Seddik Hammad*, Stefan Hoehme*, Adrian Friebel*, Iris von Recklinghausen, Amnah Othman, Brigitte Begher-Tibbe, Raymond Reif, Patricio Godoy, Tim Johann, Amruta Vartak, Klaus Golka, Petru O Bucur, Eric Vibert, Rosemarie Marchan, Bruno Christ, Steven Dooley, Christoph Meyer, Iryna Ilkavets, Uta Dahmen, Olaf Dirsch, Jan Böttger, Rolf Gebhardt, Dirk Drasdo*, Jan G Hengstler*. (2014)
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis
Archives of Toxicology 04/2014; 88 (5), 1161-1183
Citations GS (11.2015): 24

Schliess, F*, Hoehme, S* Henkel, S*, Ghallab, A*, Driesch, D, Böttger, J, Guthke, R, Pfaff, M, Hengstler, J G, Gebhardt, R, Häussinger, D, Drasdo, D, Zellmer, S. (2014)
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration
Hepatology 03/2014; 60 (6), 2040-2051
Citations GS (11.2015): 20

Patricio Godoy, Nicola J Hewitt, Ute Albrecht, Melvin E Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A Budinsky, Britta Burkhardt, Neil R Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E P Goldring, María José Gómez-Lechón, Geny M M Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M Kelm, B Kevin Park, Claus Kordes, Gerd A Kullak-Ublick, Edward L Lecluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J Naisbitt, Andreas K Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H K Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S Weiss, Agata Widera, Courtney G Woods, Jinghai James Xu, Kathy M Yarborough, Jan G Hengstler. (2013)
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
Archive für Toxikologie 08/2013; DOI:10.1007/s00204-013-1078-5
Citations GS (11.2015): 168

Drasdo, D and Hoehme, S. (2012)
Predicting the growth pattern of cell populations: pushing, pulling and the effect of an granular and cellular embedding medium
New Journal of Physics, 14, 055025
Citations GS (11.2015): 17

Hengstler, J.G., Godoy, P., Reif, R., Stewart, J., Schug, M., Heise, T., Oberemm, A., Braeuning, A., Zellmer, S., Böttger, J., Gebhardt, R., Hoehme, S., Drasdo, D., Schwarz, M. (2011)
The virtual liver. Spatial-temporal modelling of tissue damage & regeneration.
In: Seidle T, Spielmann H (Eds.): Alternative testing strategies. Progress report 2011 & AXLR8-2 Workshop report on a ‚Roadmap to innnovative toxicity testing' (pp 218-225). Berlin: AXLR8 Consortium

Drasdo, D., Hoehme, S., Hengstler, J. (2011)
A quantiative mathematical modeling approach to liver regeneration.
In Liver Regeneration. Editor: Dieter Häussinger. De Gruyter Berlin/Boston.

Hoehme, S., Hammad, S., Othman, A., vonRecklinghausen, I., Boettger, J., Gebhardt, R., Dirsch, O.,
Hengstler, J.G., Drasdo, D. (2011)
Modeling liver regeneration in a virtual lobe.
Medical Springer Edition

Drasdo, D., Hoehme, S. Hengstler, J. (2011)
Systems biology to model liver regeneration.
In Encyclopedia of Systems Biology
Dubitzky, W.; Wolkenhauer, O.; Yokota, H.; Cho, K.-H. (Eds.), Springer

Hengstler J.G., Gehrmann, M., Hoehme S., Drasdo, D., Stewart, J., Schmidt, M. (2011)
Systems biology, bioinformatics and medicine approaches to cancer progression outcomes
In Cancer Systems Biology, Bioinformatics and Medicine,
Cesario, Alfredo; Marcus, Frederick (Eds.), Springer (Read online.)

Braeuning, A., Singh, Y., B. Rignall, A. Buchmann, S. Hammad, A. Othman, I.v. Recklinghausen, P. Godoy,
Hoehme, S., Drasdo, D, Hengstler J.G., Schwarz M. (2010)
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice
Histochemistry and Cell Biology, 2010 Nov;134(5):469-81.
Citations GS (11.2015): 25

Hoehme, S. and Drasdo D. (2010)
A cell-based simulation software for multicellular systems
Bioinformatics, 2010 Oct 15;26(20):2641-2. This publication is open access.
Citations GS (11.2015): 62

Hoehme, S., Brulport, M., Bauer, A., Bedawy, E., Schormann, W., Gebhardt, R., Zellmer, S., Schwarz, M., Bockamp, E., Timmel, T., G. Hengstler, J.G., and Drasdo, D. (2010).
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
Proc. Natl. Acad. Sci. (USA), 107(23), 10371-10376. The publication is a PNAS open access article.
Citations GS (11.2015): 130 // Selected by Faculty of 1000.
Hoehme, S. and Drasdo D. (2009)
Biomechanical versus nutrient control: what determines the growth dynamics of mammalian cell populations ?
Mathematical Population Studies, 1547-724X, Volume 17, Issue 3, 2010, 166–187.
Citations GS (11.2015): 8

Hoehme, S., Hengstler J.G., Brulport M., Bauer A. and Drasdo D. (2008)
Towards modeling liver lobule regeneration in 3D
Computational Systems Biology Conference 2008 Proceedings.

Rohrschneider M., Scheuermann G., Hoehme, S. and Drasdo D. (2007)
Shape Characterization of Extracted and Simulated Tumor Samples using Topological and Geometric Measures
IEEE Engineering in Medinice and Biology Conference 2007 Proceedings, 2007, 6271-6277.

Hoehme, S., Hengstler J.G., Brulport M., Schäfer M., Bauer A., Gebhardt R. and Drasdo D. (2007)
Mathematical modelling of liver regeneration after intoxication with CCl4
Chemico-Biological Interactions, 168, 74-93
Citations GS (11.2015): 62

Drasdo, D., Hoehme, S. and Block, M. (2007)
On the Role of Physics in the Growth and Pattern Formation of Multi-Cellular Systems: What can we Learn from Individual-Cell Based Models?
Journal of Statistical Physics, Volume 128, Numbers 1-2, pp. 287-345(59)
Citations GS (11.2015): 100

Drasdo, D. and Hoehme, S. (2005)
A single-cell-based model of tumor growth in vitro: monolayers and spheroids
Physical Biology 2 133-147.
Citations GS (11.2015): 229

Drasdo, D., Dormann, S., Hoehme, S. and Deutsch, A. (2004)
Cell-Based Models of Avascular Tumor Growth
In: A. Deutsch, M. Falcke, J. Howard, W. Zimmermann (Eds.) Function and Regulation of Cellular Systems: Experiments and Models, 367-378. Birkhäuser Verlag Basel. ISBN 3-7643-6925-6

Drasdo, D. and Hoehme, S. (2003)
Individual-based approaches to birth and death in avascular tumors
Mathematical and Computer Modelling, 37 (11), 1163-1175
Citations GS (11.2015): 118

Drasdo, D. and Hoehme, S. (2002)
How do tumors grow in vitro ?
MPI MIS Preprint 114/2002.

Drasdo, D. and Hoehme, S. (2002)
Towards a quantitative single-cell based model approach to growing multicellular spheroids
In: Deformable Modeling and Soft Tissue Simulation, Ed. E. Keeve, Ayache, N., Elsevier Science.

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1052 (ISI Web of Knowledge)
1585 (Google Scholar)
Citation numbers: 05/2017