Hoehme Lab • Research group
Systems medicine • AI-based image analysis • Multiscale 3D liver models
Research interests

Our research is part of the search for understanding of the integrated physiological function of the human body in terms of structure and function of tissues, cells and proteins. Currently, we are focussing on two main objectives:
  • Technological advancement (novel algorithms, advanced programming and parallelization techniques etc.) for image processing and analysis, and 3D tissue modelling specifically exploring the possibilities of artificial intelligence.

  • Automatization and standardization of creation of 3D individual-cell-based spatio-temporal multi-scale models for biological tissue and organ structures directly from experimental image modalities.

  • Application of these models to elucidate physiological and pathological processes like liver regeneration after intoxication and partial liver resection, or carcinogenesis of hepatocellular cancer (HCC) in humans.
Collaborations
  • French National Institute for Research in Computer Science and Control (INRIA) in Paris, France >>>
  • Leibniz Research Centre for Working Environment and Human Factors (IfaDo) in Dortmund, Germany >>>
  • Helmholtz German Cancer Research Center (DKFZ) in Heidelberg, Germany >>>
  • Auckland Bioengineering Institute (ABI) in Auckland, New Zealand >>>
  • University College (UCL) in London, United Kingdom >>>
  • Chalmers University of Technology in Gothenburg, Sweden >>>
  • Molecular hepatology, University Hospital Mannheim, University of Heidelberg in Mannheim, Germany >>>
  • Fraunhofer Institute for Medical Image Computing (MEVIS) in Bremen,Germany >>>
  • Institute for Biochemistry, Medical Faculty, University of Leipzig >>>
  • Image and Signal Processing Group at the Department of Computer Science (IfI) University of Leipzig >>>
  • Bioinformatics Group at the Department of Computer Science, University of Leipzig >>>